PROFHILO

Profhilo is not a filler. This is the single most important thing to understand about it and the distinction I make clearly with every patient who comes to me having seen it described interchangeably with filler online. Profhilo works by spreading through the dermis as a slow-release reservoir of ultra-pure hyaluronic acid, stimulating the production of collagen and elastin in surrounding tissue while simultaneously improving deep dermal hydration. It does not fill. It remodels. The result is improved skin quality, texture, and laxity rather than a change in facial structure or volume.

Profhilo contains a uniquely high concentration of hyaluronic acid, 64mg per 2ml, stabilised using a patented technology called NAHYCO that combines high and low molecular weight hyaluronic acid without chemical cross-linking agents. The two molecular weights do different things in the tissue. Together they create what the manufacturer describes as a bio-remodelling effect, improving the fundamental quality of the tissue rather than adding something to it from outside. From a longevity medicine perspective, this is exactly the kind of treatment I value most. It works with the skin's own biology rather than substituting for it.

Profhilo is injected using the BAP technique, which stands for Bio Aesthetic Points. This is a standardised injection protocol developed specifically for Profhilo that places the product at five precise anatomical points on each side of the face, allowing it to spread optimally through the tissue. The injections themselves are relatively comfortable. Most patients describe a mild stinging sensation at each point that resolves within seconds. Profhilo contains lidocaine, which provides additional numbing as the product is placed, and the number of injection points is lower than many other injectable treatments, which keeps overall discomfort to a minimum.

The standard initial protocol for Profhilo is two sessions, four weeks apart. This is the clinically validated protocol and it is where the bio-remodelling effect is established. Some patients with more advanced skin laxity or quality concerns benefit from a third session before moving to maintenance, which we discuss at the two-session review. Maintenance is important. Profhilo results do not simply hold indefinitely. The collagen and elastin stimulated by the treatment continue to work for months after the initial course, but periodic maintenance ensures the bio-remodelling process continues rather than the skin gradually returning to its starting point.

Profhilo consistently produces a specific set of improvements that patients describe in remarkably similar terms regardless of age or starting skin quality. The results develop gradually over six to eight weeks following the second session as new collagen and elastin integrate into the dermal architecture. Most patients describe their skin looking healthier, more hydrated, and more vital rather than different. People around them comment that they look well rested or refreshed without identifying a specific change. This is precisely the kind of outcome I aim for.

Profhilo results typically last six to nine months before maintenance is needed. Several factors influence how long the results hold for any individual patient. Patients who maintain Profhilo consistently over years develop noticeably better skin quality than those who treat sporadically. The cumulative effect is one of the most compelling arguments for treating Profhilo as a long-term skin health investment rather than a one-off course.

Yes, and this is one of Profhilo's significant advantages over many other injectable skin quality treatments. The neck and decolletage are the areas I most commonly treat alongside the face, because these areas age in parallel with the face but are frequently ignored in aesthetic treatment plans. Patients who treat only their face while leaving the neck untreated often find the contrast between the two becomes more apparent as facial treatment progresses. Treating both together produces a more coherent and natural overall result.

Profhilo has an excellent safety profile across all skin types and Fitzpatrick classifications. Unlike ablative or energy-based treatments, it carries no risk of post-inflammatory hyperpigmentation, which makes it suitable for patients with darker skin tones who need to be more cautious with certain other aesthetic treatments. In terms of age, Profhilo is appropriate across a wide range. The youngest patients tend to use it preventatively, maintaining skin quality before significant decline occurs. Older patients use it as part of a broader regenerative protocol that may also include polynucleotides, PRP, or dermal fillers depending on their specific concerns. There is no upper age limit. The biology is always responsive to the right stimulus.

Yes, and combining Profhilo intelligently with other treatments is where the most compelling results are achieved. The general sequencing principle at Juvenology is to establish skin quality first with treatments like Profhilo and polynucleotides, then address structural concerns with filler where needed, rather than the reverse. A skin that is well hydrated and biologically optimised responds better to every other treatment it receives. Profhilo is often the foundation on which everything else is built.

All three are injectable hyaluronic acid treatments designed to improve skin hydration and quality. The differences lie in the technology, the concentration of HA, the mechanism, and what each one is best suited to achieve. Profhilo is the most sophisticated of the three in terms of its bio-remodelling mechanism and the depth of collagen and elastin stimulation it produces. Seventy Hyal 2000 is an excellent treatment in its own right, particularly for patients whose primary concern is deep hydration and skin quality improvement. The right choice depends on your specific concern, your starting skin quality, and what we are trying to achieve. This is the conversation the consultation is for.