Do Mounjaro Fat Injections Actually Work?
- Juvenology Clinic
- May 9
- 5 min read
Updated: 3 days ago
Key Takeaways:
Mounjaro fat injections are a non-surgical treatment for targeted fat reduction.
These injections help reduce stubborn fat and improve body contour, without the downtime of liposuction.
The treatment is gaining popularity, but it's important to understand its effectiveness, and potential side effects.
We'll explore whether Mounjaro fat injections can deliver the results you're looking for.
Do Mounjaro Fat Injections Actually Work?
There’s been a lot of buzz lately around Mounjaro (or tirzepatide) for fat reduction, and it’s not just because of all the success stories we hear from clients but also the side effects of the drug. It’s also stirred up a lot of conversation around the potential side effects. So, let’s break it down.
How Effective is Mounjaro in Weight Loss?
In a really exciting study called SURMOUNT-3, which was a Phase 3 trial, people using Mounjaro saw incredible results. We're talking about 24.5% weight loss on average after about 72 weeks! That’s quite a bit of weight coming off, especially when you consider it’s not a surgery. And the best part? Many people experienced over 20% weight loss, which is a big deal when it comes to health improvements, like lowering your risk for heart disease and diabetes.
The SURMOUNT-3 trial didn’t just focus on weight loss, researchers also looked at the maintenance phase. After participants had lost the weight, they were able to maintain almost 94% of the weight loss in the long term. That’s such an important point because with other weight loss treatments, the risk of regaining weight is a real concern. But with Mounjaro, it looks like the results really stick!
How Does Mounjaro Compare to Other Treatments?
If you’ve heard of semaglutide (another injectable used for weight loss), you might be wondering, “How does Mounjaro compare?” Well, the studies have been super encouraging here.
Comparison of Mounjaro with Other Weight Loss Medications
Medication | Average Weight Loss | Common Side Effects | FDA Approval |
Mounjaro | Up to 15.7% | Nausea, diarrhea, vomiting, constipation | Yes (for type 2 diabetes; weight loss off-label) |
Wegovy | Up to 15% | Nausea, diarrhea, vomiting, constipation | Yes |
Ozempic | Up to 12% | Nausea, diarrhea, vomiting, constipation | Yes |
Saxenda | Up to 10% | Nausea, diarrhea, vomiting, constipation | Yes |
Sources: Eli Lilly – SURMOUNT-2 Results
What Do the Real-World Results Show?
I always like to hear about real people’s experiences too. I mean, the studies are one thing, but hearing about someone’s actual journey makes it feel more real, right? Well, people like Bethany Diana from the UK have shared that after using Mounjaro, she lost a significant amount of weight but also noticed her bum shrinking! This is something that a few users have mentioned. It’s a bit surprising, but it’s a reminder that fat can shift from certain areas as the body sheds it.
On the flip side, Natalie Strange, a mum from Norwich, shared that she lost about seven stone and went from a size 22 to a size 10! Along with this impressive weight loss, she also saw improvements in her overall health, including better blood pressure and blood sugar levels. But of course, like with any treatment, she experienced some mild side effects like nausea in the early days. So, while the results are amazing, it's also important to be prepared for those initial adjustments.
Weight Loss Outcomes in SURPASS-1 Trial
This pivotal trial assessed the efficacy of Mounjaro in individuals with type 2 diabetes.
Dose | Mean Weight Loss | Weight Reduction ≥5% | Weight Reduction ≥20% |
5 mg | −15.0% | 85.1% | 30.0% |
10 mg | −19.5% | 88.9% | 50.1% |
15 mg | −20.9% | 90.9% | 56.7% |
Placebo | −3.1% | 34.5% | 3.1% |
Source: New England Journal of Medicine
SURMOUNT-2 Trial: Weight Loss in Obesity with Type 2 Diabetes
This study focused on individuals with obesity or overweight and type 2 diabetes.
Dose | Mean Weight Loss | Weight Reduction ≥5% | Weight Reduction ≥20% |
10 mg | −13.4% | 81.6% | 21.5% |
15 mg | −15.7% | 86.4% | 30.8% |
Placebo | −3.3% | 30.5% | 1.0% |
Source: Eli Lilly – SURMOUNT-2 Results
Understanding the Risks of Mounjaro Fat Injections
I know that when you're looking into any treatment, especially something as impactful as Mounjaro fat injections, you want to feel confident in every decision you make. While Mounjaro has certainly shown great promise for weight loss, it’s also really important to be aware of the potential risks involved. Let’s take a closer look at what we know so far, based on studies and real-world data.
1. Gastrointestinal Issues
One of the most common side effects reported with Mounjaro involves the gastrointestinal (GI) system. In fact, a systematic review and meta-analysis of 10 clinical trials with 6,836 participants found that GI adverse events (AEs) were dose-dependent—meaning they tended to get worse as the dose of the medication increased. Nausea and diarrhea were the most frequently reported symptoms. This is something that many patients experience, especially during the early stages of treatment, but the good news is that these symptoms often improve as your body adjusts. (PMC)
2. Pancreatitis
There’s also been concern around Mounjaro’s potential to increase the risk of acute pancreatitis, which is inflammation of the pancreas. A study that followed patients using weight loss injections for over 3.5 years showed that these treatments doubled the risk of developing this condition. Pancreatitis can cause severe abdominal pain, vomiting, and fever, and if left untreated, it can lead to even more serious complications like organ failure or infection. It’s something to keep in mind, especially if you have a history of pancreatic issues. (Diabetes UK)
3. Kidney Issues
Another potential concern is related to kidney function. While severe kidney problems are rare, there have been reports linking Mounjaro to acute kidney injury. This means that, in some cases, kidney function can become impaired during treatment. If you're considering Mounjaro, it's essential to keep an eye on kidney health, especially if you have pre-existing kidney conditions. Regular monitoring is key, and your healthcare provider will guide you on the best approach. (PMC)
4. Thyroid Tumours
Now, this is a more serious concern! animal studies have suggested a possible link between Mounjaro and thyroid tumours. While these findings haven’t been confirmed in humans, the U.S. FDA has issued a boxed warning regarding the potential risk of developing thyroid cancer, particularly in those with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. If this applies to you, it’s crucial to discuss alternative options with your healthcare provider before considering Mounjaro. (Drugs.com)
5. Gastroparesis and Ileus
Lastly, there have been reports of gastroparesis (delayed gastric emptying) and ileus (intestinal blockage) in some patients using Mounjaro. These conditions can result in symptoms like nausea, vomiting, and abdominal pain, and may require medical intervention. If you notice these symptoms, it’s important to seek help so your healthcare provider can assess the situation and offer solutions. (Motley Rice)
Common Side Effects in SURPASS-1 Trial
This table presents the incidence of common adverse events during the trial.
Side Effect | 5 mg | 10 mg | 15 mg | Placebo |
Nausea | 24.6% | 33.3% | 31.0% | 9.5% |
Diarrhea | 18.7% | 21.2% | 23.0% | 7.3% |
Vomiting | 8.3% | 10.7% | 12.2% | 1.7% |
Constipation | 16.8% | 17.1% | 11.7% | 5.8% |
Dyspepsia | 8.9% | 9.7% | 11.3% | 4.2% |
Source: New England Journal of Medicine
About Me
Hi, I’m Nurse Marina, and I’m so glad you’re here! As part of the National Medical Weight Loss Programme, I truly believe that weight loss should be a gradual, supported journey, always guided by qualified professionals to keep it safe and sustainable.
Before transitioning into aesthetics, I spent 6 years as a Cardiac Nurse at KIMS Hospital in Maidstone, where I developed a deep understanding of anatomy. I then honed my skills as a Specialist Aesthetics Nurse at Spencer Private Hospital in Kent.
I’m a proud member of professional organizations like JCCP, BAMAN, NMC, ACE Group, and the Royal College of Nursing. I want to make sure that every treatment I deliver is backed by the latest knowledge and techniques in medical aesthetics.
Disclaimer: This content is intended for informational and research purposes only.